I said yes since getting an ebike, but I'm just testing them on trike so far. I will probably try them on the bike once I'm a little more comfortable with them. On the recumbent bike and trike I've noticed my foot tends to move around on the pedal more, and the clip-ins keep it where it belongs. Also read where it's not if but when you fall over after having to stop and don't get your foot unclipped quickly enough.
A friend that has ridden with clipless pedals for years had to panic stop when a car pulled out in front of him a few weeks ago. He said it was all he could do to stop inches from the car and he didn't get unclipped and simply fell over on the pavement, as she drove away.