When you setup a 2wd system on the simulator, via "Two-System Mode" it has "Compare" and "Add"; you choose Add.
This then "disables" a number of "shared" controls on System B, so you can only enter the weight/etc on System A (the left side), as these are things that affect the entire setup.
Regarding "a crystalyte hub", there are multiple ones on the simulator, so you would need to specify which one for us to know, if it matters. If you wish to "save" a simulation, you can simply copy the whole URL in the URL bar of your browser, and paste that as a link (in your post if you want others to be able to see it, for instance to help you tweak it to help you find the right system).
Keep in mind that the simulator is not perfect...and not all motors are thermally modelled, so some of them will tell you "not modelled" which means the simulator has no idea if the motor will overheat or not.
But the results *generally* come close to what I see in the real world for the motors I have here that I've compared to it.
Also remember that the simulator assumes the motors / etc start from "room temperature". If your start conditions are a lot hotter, you should add taht to the final temperature, plus some, to have a better idea of final conditions. If you have several hills in a row, then unless your motor(s) have time to cool off to "room temperature" between them, the simulation of each hill won't be accurate--if a motor was already 150F at the end of the first hill, then the next one may well overheat it even though the simulation doesn't think so, because it doesnt' know it would already be hot to start with.
You can generally use a front hub and a middrive on the same bike; it's different from using two hubmotors primarily in that the middrive can be used in greater speed or torque ranges via shifting gears on the bike drivetrain (dpeending on the middrive design--most middrives don't allow shifting of the *front* chainrings, only the rear ones, at least as far as what affects the motor drive section).
If you need both speed and torque, you could use a fast-hubmotor setup on the front, and then gear the rear wheel sprockets and the ooutput sprocket of the middrive very low (very very low for 30% hills!), and then use the middrive for hillclimbing, where you mgith only get 5MPH but it'll do it all day long just fine, and the hubmotor for road use where the middrive coudln't go any faster than that 5MPH but you need to do 10 or 20MPH, for example.
BTW, the slopes in the simulator are in percentages, not degrees...if you really have a 36 degree slope (which equates to something like a 75% slope), you're likely to have some trouble even keeping both wheels in contact with the ground, much less going up it.
Red numbers are percent slopes, black are degrees.