Hey Doc,
It is so good to see another trike build!
I agree with Methods completely. If you are doing road riding and want sports car performance, stick with the small wheels. If you want to handle bumps, go with bigger wheels and soft tires.
I agree with the comment about stability too. If you plan on going more than 35mph, I would HIGHLY recommend a steering damper. I use an aftermarket damper made for a Harley. That allows up to 70mph safely (ask me how I know !
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Anyway, I am so excited to see your build come together.
Oh, lastly, if you want to keep it low as a road racer, I have 43mm wide 16 inch 32 hole rims in stock that I had made for KMXs. I would also recommend running the widest rims you can find, no matter what diameter they are. This thing is more like a car than a bike. You need to think outside the box.
Matt