So.. Merck's new drug has turned out to be a flop.
I recently read more about Pfizer's new Covid drug and how it works.
It's a proteoloytic enzyme inhibitor and works on the same action as Ivermectin.
From a 'synthetic benchmark' of 3CLPro enzyme inhibition ( the same method pharmaceutical companies use to find new drug candidates ):
Drugs that target 3CLPro also work on the original SARS-COV and many other coronaviruses. We knew this since 2003:
https://www.science.org/doi/10.1126/science.1085658
So now that we know Ivermectin and Pfizer's drug work similarly..
Pharmaceutical industry apologists' best and closest to valid argument is that Ivermectin does not have enough activity at 3CLPro..
Example:
https://sciencebasedmedicine.org/pf...bitor-drug-is-not-just-repackaged-ivermectin/
The LD50 of Ivermectin, if you translated 25mg/kg ( mouse number ) to humans, for a 80kg human, would be 2000mg.
Ivermectin is usually given as 5-15mg tablets.. and there is plenty of room to increase the dosage given the excellent safety profile of ivermectin ( vs other antivirals ) and have effective CL3Pro action.
Another thing is that the FDA and many other western health organizations set an artificial cap on the dosage of Ivermectin that can be administered. So i don't know of any western scientific journals publishing clinical trials of Ivermectin at high doses.
So even this apologist talking point goes poof when you consider that proper western research on Ivermectin is blockaded. You can't say Ivermectin doesn't work when you haven't tested it at doses appropriate for the application.
I'm more and more veering in the direction that the key source of misinformation has been pharmaceutical companies looking to make more and more money, and using media and government influence to make sure that message is heard and others aren't.
Pfizer is making a new vaccine for the omicron variant now but it's going to take 100 days. In that time, Omicron will have run most of, if not all of it's course.
What will Pfizer's Paxlovid cost? Well, the United States government just handed Pfizer 5.3 billion USD for 10 million courses, which works out to $530 per "course". So the real cost to consumer/insurer is probably beyond that.
This is
a lot cheaper and
a lot more effective than a week in the hospital, so people are going to pick the pill when they get sick... and Pfizer could make a trillion dollars or two selling it to the world.
I just think about how we could have avoided the hospital overrun problem, a ton of deaths, the lockdowns, the viral mutations, etc by using a drug like Ivermectin from the start. I also ask why Hydroxychloroquine, with it's very poor results in clinical practice, and also in clinical trials, was EVER chosen over Ivermectin ..?
