From a functional advantage of higher voltage systems, my trail bike with an etek motor will be set up for 48v. Its geared for ~45 mph and draws 100-300amps. I'm really not a speed person and 35mph is closer to my top speed. So for more range, I may change the gear ratios (less amps) for ~35mph. There will be also less heat loss (22%) in the cables, batteries, controller and motor. And more torque and zip for hills. I'm using 8 and 6 gauge cables, small crimp lug terminals and Deans connectors.
If I was running 800-1000amps, 1-2 gauge cables, fork lift connectors and truck size terminals. I also use 10, 30amp auto fuses for the batteries. A 800-1000amp fuse will be large and expensive.
In my hobby life time, affordable batteries that can equal gasoline in energy will not happen. And at the end of each e-bike design was the problem of range. So designing a bike that is energy efficent and light weight would make the most of what battery technology we have.
Wes