I would use double-ended axles, with frame around the wheel. Aside from the doubled ability to resist axle torque from hub motor power, it also provides almost doubled support for the cargo load, since the inboard axle, dropout, and frame isn't supporting the whole thing and bending on every bump.
LIke either of my trailers here:
Teh small one, which can't take nearly the load the big one can, more because of the way I used the BMX forks than it's size; they're flexy enough with only forward-end outboard support that they still allow wheel to cant inward at the top under heavy loads (have several fixes I could do to prevent that, but never did them cuz I built the big one and have rarely used the little one since then).
https://endless-sphere.com/forums/viewtopic.php?f=2&t=63781
The big one (which now has duallies so I could carry a piano a while back) has wheels that go in from the top so a wheel or tire can be changed without unloading it. But the best part about it is it keeps the deck / load down low, but has large diameter wheels that give it a MUCH better ride than the little wheels on the small trailer. These pics are from when I was tacking it together to ensure it was built right before fully welding it all:
https://endless-sphere.com/forums/viewtopic.php?f=2&t=76539#p1158726
Depending on your needs, you could use DD hubmotors so you can have trailer braking (regen), or two geared hubs. hubmotors make the drivetrain very simple to implement; no need for live-axles or complicated chainlines or whatever, which can happen with "middrives" of various kinds.
On my big trailer, with duallies, I have a "plan" to use DD hubmotor wheels for the inboard pair (since they'll have more of the load on them they'll have better traction), and can use them for braking, too. Then two regular bike wheels on the outboard pair, for the strength they have over most hubmotor builds.
I had also "planned" to use a pair of powerchair brushed motor wheels (small airless tires, around 14" diameter) on the trailer, instead of the bike wheels, but the disadvantages of the small tires are high. Another plan would put sprockets on the output of the powerchair motors, and use rear wheels on the trailer instead of front wheels, and drive the wheels via chain. But no braking that way, unless I locked the freewheels on the wheels, or used disc-brake-mount sprockets on the wheels (could use front or rear for those, but prefer front).
For throttle control, there is actually an automated way to handle it, I think discussed in one of my trailer threads above. Basically you make the trailer hitch telescoping with springs (gas or coil or whatever), and a "plunger" potentiometer (or similar) that is moved by the trailer moving forward and backward along the telescoping hitch (or a strain gauge on a fixed hitch). This can be setup so that whenever the trailer is being pulled on, the throttle output increases until it reaches a neutral position; if it begins pushing on the bike harder than a set amount, then it decreases throttle, and it just keeps balancing around this point so it's "neutralizing" the mass and rolling resistance and air resistance of the trailer and load. If throttle decreases to zero and it's still pushing on the bike, it engages the regen braking, until again it reaches that balance point. I'm sure it can be done without a Cycle Analyst, but since that's designed to take a voltage input of varying types and convert it into a throttle output, it'd probably be easier ot use one.
Then the bike's own motor handles it's own load.
You could of course use a throttle on the bars, or a CA to convert your PAS control to a throttle signal, and run that back to the trailer.
I've yet to power one of my trailers, but I keep planning different ways to actually do it.