The only thing I have seen so far on my massive-torque CrazyBike2 is that if you startup in higher gears the chain will ride up on the tips of the rear cassette sprockets, and start bending the tips a little, and then it will start slipping right over them, popping a whole link's length or more before it catches and starts to actually move the bike. A few times of this and the sprockets become toast unless you have reversible ones to flip over and use the other side.
The front chainring sets are large enough with enough teeth engaged it doesn't seem to be any problem at all, unless the chain is misaligned, and in that case it is possible to taco the rings at high torque levels with a very heavy bike and load (300+ pounds including me).
Other than those two issues, both of which are easy to prevent, it's not a big deal that I can see.