On the ebikes.ca spoke calculator page re: radial lacing " In spite of popular wisdom not to use radial lacing on drive wheels,empirical experience has been that this isn't really an issue with the large hubs in small rims.

Building a wheel that is five - ten times stronger and much heavier than is required just to over compensate for poor / no engineering is considered acceptable, just to make it easier to build.

The saying "Overbuild it! Use a thick pencil", the old timers would say." Great for bridges, buildings and tractors, but not flight hardware. Curious if any of the high powered builds out there have had long term luck. I have never seen a motorcycle with radial drive. Sure that folks have tried it. On the e-bike with a DD motor, you would not have popping clutches, clutch less shifts, and hard down shifts to deal with, but still have to face the daily grind. As long as you stay within the elastic limits of the components, it should hold up.
" Sheldon Browns reasoning in favor of using Loctite on the spoke threads when radial lacing makes sense to me.