From u/gengisK4HN (a poster on reddit.com)
Let's start with India
https://www.reddit.com/r/ivermectin/comments/p9q5yr/indias_ivermectin_blackout_dheli_obliterating_the/?utm_medium=android_app&utm_source=share
Hope it helps!
Panel review of ivermectin reporting that "ivermectin in the dose of 12mg BD alone or in combination with other therapy for 5–7 days may be considered as safe therapeutic option for mild moderate or severe cases of Covid-19 infection. https://www.sciencedirect.com/science/article/abs/pii/S0019570720301025
Retrospective 148 hospitalized patients showing triple therapy with ivermectin atorvastatin N-acetylcysteine resulted in a 1.35% case fatality rate which was well below the national average. https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/October/observational-study-on-clinical-features-treatment-and-outcome-of-covid-19-in-a-tertiary-care-centre-in-india--a-retrospective-case-series_October_2020_1614017661_0932284.pdf
Ivermectin shortens durations of symptoms from 10 days to 3 days. https://www.biomedres.info/biomedical-research/effects-of-ivermectinazithromycincholecalciferol-combined-therapy-on-covid19-infected-patients-a-proof-of-concept-study-14435.html
Review suggesting that ivermectin may be useful for late stage COVID-19. Authors note that ivermectin, in doses at or modestly above the standard clinical dose, may have important clinical potential for managing disorders associated with life-threatening respiratory distress and cytokine storm, such as advanced COVID-19. https://openheart.bmj.com/content/7/2/e001350
Ivermectin lowered deaths by 87.9% in a study from Argentina https://www.medrxiv.org/content/10.1101/2020.09.10.20191619v1
Retrospective study of 115 ivermectin patients and 133 control patients showing significantly lower death and faster viral clearance with Ivermectin https://www.archbronconeumol.org/en-ivermectin-treatment-may-improve-prognosis-articulo-S030028962030288X
A study showing that ivermectin is capable of interfering in different key steps of the SARS-CoV-2 replication cycle. https://chemrxiv.org/articles/preprint/Has_Ivermectin_Virus-Directed_Effects_against_SARS-CoV-2_Rationalizing_the_Action_of_a_Potential_Multitarget_Antiviral_Agent/12782258/1
RCT for ivermectin doxycycline showing improvements in mortality, recovery, progression, and virological cure. https://journals.sagepub.com/doi/10.1177/03000605211013550
How does it work? The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article https://www.nature.com/articles/s41429-021-00430-5
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro. A single treatment able to effect ~5000-fold reduction in virus at 48 h in cell culture.
https://www.sciencedirect.com/science/article/pii/S0166354220302011
Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?
Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID-19).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564151/
Ivermectin for COVID-19: real-time meta analysis of 60 studies • Meta analysis using the most serious outcome reported shows 76% and 85% improvement for early treatment and prophylaxis (RR 0.24 [0.14-0.41] and 0.15 [0.09-0.25]), with similar results after exclusion based sensitivity analysis, restriction to peer-reviewed studies, and restriction to Randomized Controlled Trials. • 81% and 96% lower mortality is observed for early treatment and prophylaxis (RR 0.19 [0.07-0.54] and 0.04 [0.00-0.58]). Statistically significant improvements are seen for mortality, ventilation, hospitalization, cases, and viral clearance. 28 studies show statistically significant improvements in isolation. https://ivmmeta.com/
Ivermectin has been found to reduce COVID-19 mortality by 81% https://archive.is/g11nU
It’s also safe, inexpensive and widely available, with decades of clinical usage suggesting it has a “high margin of safety.” https://pubmed.ncbi.nlm.nih.gov/26954318/
In one trial, 58 volunteers took 12 milligrams of ivermectin once per month for four months. Only four (6.96%) came down with mild COVID-19 symptoms during the May through August 2020 trial period. In comparison, 44 of 60 health care workers (73.3%) who had declined the medication were diagnosed with COVID-19.
https://www.ejmed.org/index.php/ejmed/article/view/599
If you were to say, tell me the characteristics of a perfect drug to treat COVID-19, what would you ask for?’ he [Marik] said. ‘I think you would ask firstly for something that’s safe, that’s cheap, that’s readily available, and has anti-viral and anti-inflammatory properties.
People would say, ‘That’s ridiculous. There could not possibly be a drug that has all of those characteristics. That’s just unreasonable. But we do have such a drug. The drug is called Ivermectin.’
If it was universally distributed at a dose that costs ten American cents in India and about the cost of a Big Mac in the United States, he said, Ivermectin would save countless lives, crush variants, eliminate the need for endless big pharma booster shots, and end the pandemic all over the world.”
https://www.sciencedirect.com/science/article/pii/S0166354220302011
In June 2020, a study also found ivermectin inhibits the replication of SARS-CoV-2 in vitro, with a single treatment leading to a 5,000-fold reduction in virus after 48 hours.
https://www.sciencedirect.com/science/article/pii/S0166354220302011
3.7 billion doses have been administered in the last 40 years, with serious side effects extremely rare
https://www.mountainhomemag.com/2021/05/01/356270/the-drug-that-cracked-covid
“‘We have a solution to this crisis,’ he said. ‘There is a drug that is proving to be of miraculous impact,’ ...‘When I say miracle, I do not use that term lightly. And I don’t want to be sensationalized when I say that.
It’s a scientific recommendation based on mountains of data that has emerged in the last three months … from many centers and countries around the world showing the miraculous effectiveness of Ivermectin. It basically obliterates transmission of this virus. If you take it, you will not get sick.’”
https://covid19criticalcare.com/
Mexico City starts handing out Ivermectin to the Covid positives, hospitalizations plummet. Facebook still tells me Ivermectin is dangerous. https://trialsitenews.com/mexico-city-wide-innovative-population-level-study-administers-ivermectin-based-home-kits-with-drastic-reduction-in-hospitalizations/
India covid cases plummet 80% to 90% after states embrace Ivermectin, one state bans ivermectin treatment: cases have tripled https://www.thedesertreview.com/opinion/letters_to_editor/is-ivermectin-the-new-penicillin/article_b6b7afd8-bd77-11eb-8259-af11e3c83aea.html
How it works
Firstly it docks to ace2 receptor sites so when sars-cov tries to use it's spike protein (the proteins the vaccines teach your body to produce via RNA) to latch onto the ace2 receptor, it is completely blocked from doing so. Can't latch on, can't infect. Ivermectin literally docks itself to the spike protein and the receptor for that spike protein.
But wait there's more. Ivermectin binds to glutamate-gated CHLORIDE channels bin the membranes of invertebrate nerve and muscle cells causing INCREASED PERMEABILITY TO CHLORIDE IONS, resulting in cellular hyper-polarizarion followed by paralysis and virus-cell death's
Not only does it get directly in between the sars-cov spike protein and the ace2 receptors it binds to (preventing further infection) but it also opens channels for chloride to enter cells and kill the viruses that way...like a disinfectant. https://pubmed.ncbi.nlm.nih.gov/32871846/
The numbers in Delhi after they included Ivermectin in the protocol. Delhi is a city with 30 million inhabitants and, as of August 11, saw 37 new cases and ZERO deaths. By contrast, Tamil Nadu, a city of 78 million, saw 1964 new cases and 28 new deaths.
Tamil Nadu shares their rejection of Ivermectin and choose to use Remdesivir (from Gilead Pharma) in common with the United States.
As of August 10, the United States, with 331 million inhabitants, saw 161,990 new cases and 1,049 new deaths. Uttar Pradesh is a state in India of comparable population to the US. Uttar Pradesh contains 241 million people. On August 10, Uttar Pradesh saw only 19 new cases and ONE death, over 1,000 times lower than the US.
The evidence in favor of Ivermectin is massive and overwhelming, which includes W.H.O. scientists Drs. Tess Lawrie's and Andrew Hill's recent highly-regarded and peer-reviewed publications [for anyone who wishes to show scientific data to their doctors]:
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab358/6316214
https://pubmed.ncbi.nlm.nih.gov/34145166/
Dr. Pierre Kory also published a review:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088823/
Dr. Peter McCullough similarly published via preprint yet another review and all of these strongly showed the drug to be safe and effective against COVID-19.
https://www.medrxiv.org/content/10.1101/2021.07.06.21259924v1
What should alarm any reader is that Dr. Tess Lawrie reports that Dr. Andrew Hill's paper's conclusion was changed by his sponsor, and Dr. Hill was given a gag order on speaking to the media.
