I am very interested in this topic as well.
I built a Mid Drive Commuter recently, and bought a Nuvinci N171b Developer's Kit on a whim for cheap, but once I started reading up on them, I realized the efficiency might be an issue.
I started tracking my average watt-hours based on my average commute and after 200+ Miles of riding, I am getting an average efficiency of 13.5 Watts per mile. This is with an 8-speed rear derailuer and a single 48T chainring.
I have not yet invested in the additional costs of Lacing my Nuvinci hub into a wheel and installing on the bike, and actually am thinking I would just sell the Nuvinci.
I think what needs to happen for a really scientific analysis is for someone to track average watts per mile before (Like I have done) and then after installing the Nuvinci Hub. I think it will also take a bit of "playing around" with the exact rear cog size, and shift profile of the hub to dial it in to the bike for maximum efficiency.
My thought was to size my rear cog so that the 1:1 ratio of the Nuvinci would be at my ideal gear ratio and speed on the flat - for me, that is a 16T rear Cog and 16 MPH, at a cadence of around 68 RPM. (Yes, I am a lazy pedaler)- This would in theory maximize my efficiency for the CVT.